The IJM NanoScaler is made with research and development and lab-scale production in mind.
Equipped with our proven Impingement Jets Mixing (IJM) technology for the production of lipid nanoparticles the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.
The NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab. The system comes with five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation. In addition researchers can use their own custom mixing unit and benefit from the flexibility of the system set-up.
The encapsulation process can be remotely controlled by software; ran from a conventional PC or laptop, or even a tablet.
With our preconfigured Upgrade-Kits you can upgrade your IJM NanoScaler very easily and build up the system you need.
IJM NanoScaler
IJM NanoScaler: System setup
Flowchart IJM NanoScaler
Highly reproducible results
Flexible and modular
Customized solutions
Certified quality management
Made in Germany
| Fields of applications | LNP Research and Development (R&D) |
|---|---|
| Number of impingement jets mixers | 5 |
| Number of pumps | 3 |
| Number of valves | 2 |
| Process connection inlet | 1/8“ OD, 2.1 mm, ID FEP tubing (UNF 1/4-28 thread, flat bottom) |
| Process connection outlet | 1/16“ OD, 0.5 mm, ID PEEK tubing (UNF 10-32, thread coned) |
| Volumetric flow rate (L/min) | up to 0.05 liter/min |
| Volumetric flow rate (L/hour) | 3 |
| Maximum operation pressure | 140 bar (2030 psi) |
| Liquid temperature range | 4−60 °C (39.2−140 °F) |
| Wetted materials | Titanium, stainless steel, PEEK, GFP (graphite fiber reinforced PTFE), FFKM, PTFE, FEP, UHMW PE, ruby, aluminum oxide (Al2O3), sapphire, Zirconium oxide, POM, Tefzel® (ETFC) |
| Software | CDS, 21 CFR part 11 compliant |
| Ambient conditions | Temperature range: 4–40 °C; 39.2–104 °F; humidity: below 90 % (non condensing) |
Expand the IJM NanoScaler with an additional injection valve - minimise the consumption of encapsulation material for the production of nanoparticles in small quantities
Article No.: A71103
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Expand the IJM NanoScaler with three additional flow meters - monitor the flow rate of all pumps for product and process control
Article No.: A71114
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Mobile Control LNP for control of IJM NanoScaler systems
Article No.: A96133
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KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
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In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity
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