Cyclodextrins (CD) are macrocyclic compounds composed of five or more glycopyranosides. These ring structures can function as micro-capsules. Hence, CDs often find interesting applications in drug delivery. In this application, five CDs were purified in high purity from a CD mixture derived from a biocatalytic synthesis.
Separation of CDmix on C18H 250x20mm column, 2 mL injection, 100 mg/mL CD mix; indication of collected fractions
Overlay analytical chromatograms of CDmix and the fractions collected from purification step (Fig. 1) black Frc1; red Frc2, light blue Frc3, yellow Frc4, green and blue Frc5/Frc6
| Method | Preparative HPLC |
|---|
| Mode | RP |
|---|---|
| Substances | Cyclodextrine (CD), CD8, CD9, CD10, CD11, CD12 |
| Key words | Cyclodextrine mixture, preparative LC, RP, pharma, synthesis |
| CAS number | - |
AZURA® Pump P 2.1L with 100 ml pump head (stainless steel)
Article No.: APE20KA
Show product
LPG module for Pump P 2.1L ternary up to 220 ml/min (stainless steel)
Article No.: AZZ00AB
Show product
AZURA® RID 2.1L high-flow preparative refractive index detector with flow cell and external pressure release valve
Article No.: ADD38
Show product
Article No.: 25WE185E2J
Show product
Basic License for one system
Article No.: A2650
Show product
Easy-to-use method transfer software from analytical to preparative HPLC. Save all the hard work using formulas to calculate your scale up method parameters when going from analytical to preparative HPLC.
Article No.: A1696
Show productWe are happy to help you
