Cyclodextrins (CD) are macrocyclic compounds composed of five or more glycopyranosides. These ring structures can function as micro-capsules. Hence, CDs often find interesting applications in drug delivery. In this application, five CDs were purified in high purity from a CD mixture derived from a biocatalytic synthesis.
Separation of CDmix on C18H 250x20mm column, 2 mL injection, 100 mg/mL CD mix; indication of collected fractions
Overlay analytical chromatograms of CDmix and the fractions collected from purification step (Fig. 1) black Frc1; red Frc2, light blue Frc3, yellow Frc4, green and blue Frc5/Frc6
|Substances||Cyclodextrine (CD), CD8, CD9, CD10, CD11, CD12|
|Key words||Cyclodextrine mixture, preparative LC, RP, pharma, synthesis|
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