Robust Autosampler for preparative LC

preparative HPLC autosampler

The Autosampler AS 6.1L can inject from up to 768 positions when equipped with microtiter plates (either high or low formats) or from up to 108 standard 1.5 ml sample vials. Sample carryover is significantly minimized thanks to a highly-effective interior and exterior needle wash procedure. This autosampler is also fast and flexible: one complete sample injection cycle takes less than one minute, including needle wash. Three different injection modes are supported; “full loop filling” (highest precision and reproducibility), “partial loop filling” (variable volumes, e.g. for dilution series) and “µl pickup” (loss-free injection of extremely small sample volumes), allowing the user to optimize sample usage. The headspace pressure function prevents bubbles from forming in the vial during sample uptake. Precolumn derivatization is supported.
Preparative version for sample volumes up to 10 ml.

The accessory kit includes a vial plate for 30x 10 ml vials (A500507).

Key Features

High precision injection

Low carry-over due to efficient needle wash

Supports three injection modes: full loop, partial loop filling, and µl pickup

Headspace pressure function prevents bubbles at sample uptake

Autosampler Flow Path	Preparative
Maximum back pressure	350 bar
Vial/plate dimensions	well plate dimensions according to ANSI SLAS 4-2004 (formerly ANSI/SBS 4-2004) max. plate/vial height: 47 mm (incl. septa or capmat)
Injection volume range	0.1 µl–10 ml depending on sample loop
Sample loop	10 ml
Dispenser syringe	2500 µl
Headspace pressure	built-in compressor, only for sample vials with septum
Switching time inj. valve	< 100 ms
Piercing needle precision	± 0.6 mm
Sample tray cooling	None
Vial detection	missing vial/well plate detection by sensor
Wetted materials	ETFE (buffer & needle tubing), stainless steel (sample needle, valve stator), PEEK (rotor seal), Kel-F (syringe valve), glass (syringe), PTFE (tip of syringe plunger)

Injection modes	partial loop filling
Injection precision	full loop filling: < 0.3 % RSD partial loop injection at injection volumes>5 µl: <0.5% RSD microliter pickup at injections>5 µl: <1.0% RSD
Sample carryover	< 0.1 % with standard needle wash
Injections per vial	max. 9 injections
Injection cycle time	minimum 7 s from the same vial, 14 s from different vials;< 60 s for>100 µl sample injection in all injection modes, incl. 300 µl needle wash
Analysis time	max. 9 h, 59 min, 59 s

Inputs	2 programmable TTL inputs (next injection, freeze, stop)
Outputs	1 programmable relay output (inject marker, auxiliary, alarm)
Control	Ethernet (LAN)
Interfaces	LAN, analog

Ambient conditions	temperature range: 10–40 °C; 50–104 °F air humidity: 20–80%

Power supply	95–240 V AC
Dimensions	364 x 379 x 567 mm (W x H x D)
Weight	30 kg

Certified Quality

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates

In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity

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