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KNAUER LH 8.1 - Modular analytical XYZ Autosampler

KNAUER Liquid Handler offers finally an alternative in the world of robotic autosamplers. In-house design and development for a new level of simplicity and speed

Performance

  • Highest repeatability of peak area in full loop or sandwich injection mode
  • Zero sample loss and high precision via Sandwich injection mode 
  • Lowest carry over with active Fast wash station that cleans the injection syringe and needle on the in- and outside by delivering an adjustable cleaning solvent flow
  • User-friendly control via pre programmed injection parameters in Chromatography Software packages

Versatility

  • Modular design and wide selection of accessories
  • Flexible injection volumes by a variety of exchangeable injection syringes 
  • Customizable lengths of the rail from standard  557 or 887 mm up to 1200mm to increase the amount of modules

High throughput

  • Up to 390 x 1.5 mL vials or 6 well plates per Robotic Cooler
  • Maximum 1560 x 1.5 ml vials or 24 well plates per Liquid Handler
  • Short cycle times via fast and precise movements and the software option "overlapped injections" that allows for preparing the next injection while the previous is still running

Great variety of modules available

KNAUER offers a range of active and passive modules for easy customisation of your LH 8.1. 

Want to have more samples and need a cooling option? Use the Robotic Cooler!
Want a lower carry over? Install the Fast Wash Station with two different solvents for in- and outside syringe and needle cleaning!
Want to change the solvent in your syringe? Use a passive solvent option to draw liquid during the injection process!

There are a variety of active and passive options available. Just mount the module on the sampler, configure it in your software and you are ready to go. 

Sandwich Injection Mode: Zero sample loss with excellent reproducibility

Tired of choosing between sample loss and high performance?
The new injection mode offers both.


KNAUER Liquid Handler LH 8.1 has a special injection mode. Next to standard injections like full loop and partial loop it has the opportunity to use the sandwich injection mode. 

The sample is prepared inside a gastight syringe and then transferred into the HPLC System. In sandwich mode the sample is trapped between small gaps of air. This injection method only takes up the sample volume it needs and the air gaps prevent any peak broadening. Furthermore the pressure increase during the injection process will reduce the sample plug even more leading ot much narrower peak shapes and higher injection precision.  
Ths injection method combines the zero sample loss of µl pickup and injection precision of partial loop injection. 

Injection modes

Large number of samples for high-throughput applications

The Robotic Cooler offers space for up to 390 x 1.5 ml standard sample vials while maintaining a stable temperature. 
 

The Robotic Cooler compartment offers 6 places for sample racks. Two per drawer with a variety of options. One place can be used by a 60 x 1.5 ml vial rack, or 384 well plates or 96 well plates. Furthermore a double rack can be used to offer 130 x 1.5 mL vial positions, taking the total sample capacity to 390 x 1.5 ml vials.

Depending on the rail length a multitude of Robotic Coolers can be installed and used seperatly. Up to 4 Robotic Coolers on the longest rail. 

The Robotic Cooler is software controlled, which enables a higher response speed and only open the doors so the injection syringe can reach the sample, to protect other samples from temperature fluctuations. 

Speed up your injection

The LH 8.1 is optimized to save time during injection and movement.

To safe time during the movement, the opening of the Robotic Cooler is software controlled and happens automatically. 
To further speed up the injection, the sampler can apply the "overlapped injections" function, where the sample is already prepared inside the syringe. Then the sample can be injected directly after the end of the previous run. 
 

Easy control via HPLC software 

The LH 8.1 can be used just as comfortable as any HPLC Autosampler. All parameters for recommended syringes, like injection speed, delay and sandwich build-up are already implemented and extensively tested in our Chromatography Software packages, so that you are ready to go!

As an example, ClarityChrom can be used:

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