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Quality Control of Cannabis Products
From quick methods for THC determination to highly sensitive analyses of the most interesting cannabinoids
From quick methods for THC determination to highly sensitive analyses of the most interesting cannabinoids
With more and more countries legalizing medical cannabis every year, also a growing number of analytical methods and instruments is available.
The main biologically active components of cannabis and hemp plants are naturally occurring cannabinoids. 70 of these closely related compounds are already known and well described. The primary focus has been on Δ9-tetrahydrocannabinol (THC) due to its pharmacological and toxicological characteristics, upon which strict legal limits have been enforced.
Also of growing interest is Cannabidiol (CBD), the second most prevalent of the active ingredients of cannabis. CBD was labelled as having no public health risk or abuse potential by the World Health Organization (WHO) in 2017. CBD is commonly used to address anxiety, insomnia and different types of chronic pain.
Potency testing: Simplified analysis of THC content
Beside Δ9-tetrahydrocannabinol (THC), cultivators and processing labs often focus on Δ9-tetrahydrocannabinolic acid (THC-A), as it is the naturally occurring precursor to THC and is readily decarboxylated to THC via the drying and/or heating of cannabis. Therefore, an easy and quick method for the determination of the THC and THC-A content of a cannabis sample is of great interest.
Cannabinoid profiling: Detailed analysis of all main cannabinoids
Whenever the focus lies on the whole profile of cannabinoids and not only on potency testing, more sophisticated HPLC systems and methods have to be applied. KNAUER established a method and a dedicated HPLC system for the determination and quantification of the 16 well known cannabinoids.
Whether your lab is well established or just starting up, KNAUER can offer turnkey solutions that help you meet regional regulations that are essential to a successful business. Our more than 55 years expertise in HPLC brings confindence to this very new application field for Germany.
KNAUER can also assist you finding the perfect preparative method for purification of cannabinoids like CBD. Contact us if you want to learn more!
This application shows that six common cannabinoids of high medicinal interest can easily be quantified according to the monography of German Pharmacopeia. Included in this is the quick and easy determination and quantification of the cannabinoids of especially high interest: THC, THC-A and CBD.
Cannabis contains more than 500 unique compounds, including over 80 chemical alkaloids known as cannabinoids. Manyof them are known to have pharmacological effects and medicinal benefits that could be very different. Therefore, it is of hogh industrial ineterest to determine the profile of the most occuring cannabinoids in a cannabis product. Thsi method easily separates and quantifies 16 cannabinoids.
One of the 10 most dangerous chemicals in the world is the aflatoxin B1. For both, humans and animals the consumption of the toxic aflatoxins can lead to serious health damage. They are produced by mold fungi on food and feed products. Herewith, a simple, robust and highly sensitive method for the analysis of aflatoxins in food and feed is provided to ensure consumer safety. Also in cannabis products, it is crucial for those involved with the quality and safety testing to consider naturally occurring sources of contamination.
This AZURA Analytical system is dedicated for the analysis of six common cannabinoids of high medicinal interest. Cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN), Δ8-tetrahydrocannabinol (Δ8-THC), Δ9-tetrahydrocannabinol (Δ9-THC), and Δ9-tetrahydrocannabinolic acid (Δ9-THCA) can easily be quantified according to the monography of German Pharmacopeia.
How can liquid chromatography support cannabis testing applications? Liquid chromatography is implemented in numerous ways to help professionals on either side of the cannabis market’s gulf in legitimacy.
Analytical HPLC is often used in cannabis analysis to detect and quantify different cannabinoids. Find out which advantages HPLC offers for quality control and potency testing.
Preparative HPLC is proving instrumental to the extraction and purification process, assisting in the production of extremely high quality, pure CBD extracts.
We are the experts for HPLC
Analytic HPLC, preparative HPLC or SMB - we do it all
Certified products and methods
Own application department
HPLC system for the quick and easy determination of 16 cannabinoids in 20 minutes.
Preparative HPLC system for the purification of single cannabinoids from extracts of cannabis flos or cannabinoid oil.
Simulated moving bed (SMB) chromatography sets the benchmark for productivity, purity and yield in the continuous production of cannabinoids.
Disclaimer:
KNAUER does not endorse the use of its products in connection with the illegal use, cultivation or trade of cannabis products. KNAUER does not endorse the illicit use of marijuana, we merely provide an overview of the methods and systems of cannabis analysis.
