| Batch chromatography (single-column) | SMB chromatography (multi-column) |
| Unlimited number of fractions | Two fractions, no waste |
| Recovery typically below 80 % | Recovery up to 100 % |
| EITHER high purity OR high yield | High purity AND high yield |
| Isocratic or gradient | Isocratic (step gradient possible) |
| High solvent consumption Can be as low as 10 % of batch consumption Very diluted product | Product concentration comparable with input concentration (feed) |
