Customized impingement jets mixing skid for large production scale

Production-scale Impingement Jets Mixing (IJM) Skid for the high flow production of lipid nanoparticles (LNP, microemulsions, etc.)

The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

up to 16 KNAUER high-pressure dosing pumps 80P
up to 16 Coriolis flow meters
up to 8 KNAUER IJM mixers
Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
Outlet manifold for LNP solution
Back-seal washing system
The frame (stainless steel system 1.4301)
Installation & familiarization by KNAUER

In addition, we offer for our customers:

Customized Technical documentation which is order- and article-related
Customer Service before, during, and after the setup
Capillary customization and labeling
FAT (Factory Acceptance Test at KNAUER Berlin)
SAT (Site Acceptance Test at customer site)

The skid-based NanoProducer units like the one shown require sophisticated craftsmenship and know-how. That's why they are exclusively designed, certified & distributed only directly by KNAUER Germany. The same applies for the offered additional services.

Key Features

Made in Germany

Certified quality management

Customized solutions

Dedicated customer support

Fields of applications	LNP production
Number of impingement jets mixers	up to 8
Number of pumps	up to 16
Number of flow meters	up to 16
Process connection inlet	Sanitary Clamp Connector (2 Inlets)
Process connection outlet	Sanitary Clamp Connector (1 Outlet)
Volumetric flow rate (L/min)	depending on configuration
Volumetric flow rate (L/hour)	depending on configuration
Maximum operation pressure	50-70 bar
Liquid temperature range	4−60 °C (39.2−140 °F)
Wetted materials	stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al₂O₃), ruby, sapphire
Software	not included, necessary interfaces for the integration into PLC available
Interfaces	Pump: LAN, RS-232, pin header connectors; Flow meter: RS-232 + Industrial Interfaces; Valve drive: LAN
Power supply	Pump: 100–240 V, 50–60 Hz; Flow meter: +15…24 V DC,
Maximum power consumption	Values per device Pump: maximum 320 W; Flow meter: 3 W
Ambient conditions	Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions	depending on configuration
Weight	depending on configuration
API-predilution and quenching	depending on configuration
GMP-ready documentation	Yes
Factory acceptance test	Yes
Site acceptance test	Yes
Purchase order lead time	minimum 5 months, depending on customer requirements
Disclaimer	Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

Certified Quality

KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates

In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity

Innovation and quality - since 1962. Made in Germany.