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Investigation of system performance – of the KNAUER AZURA® UHPLC system

Applikationsnr.: VTN0023

Investigation of system performance – of the KNAUER AZURA® UHPLC system

Although time is relative, the total run time of a method is an important factor when it comes to high throughput analysis. Saving time means saving money. With the exemplary separation of compounds that are present in anti-epileptic drugs, the KNAUER AZURA UHPLC system equipped with the new binary AZURA P 8.1L pump, thanks to the low dispersion and operating pressure up to 1240 bar, allows to speed up your method and increase throughput preserving resolution.

  • Chromatogram at 0.2 ml/min, (1) caffeine, (2) PEMA, (3) ethosuximide, (4) primidone, (5) carbamazepine, (6) phenytoin

  • Chromatogram at 1.5 ml/min, (1) caffeine, (2) PEMA, (3) ethosuximide, (4) primidone, (5) carbamazepine, (6) phenytoin

  • Overlay of chromatograms at different flow rates, dark blue- 0.2 ml/ min, red – 0.6 ml/min, black – 1.2 ml/min, light blue – 1.5 ml/min

  • Standard deviation of retention time over 10 replicates for each flow rate

  • Normalized overlay of primidone (peak 4), dark blue- 0.2 ml/min, red – 0.6 ml/min, black – 1.2 ml/min, light blue – 1.5 ml/min

  • Van Deemter plots

Technische Daten

Spezifikationen

Methode UHPLC
Modus RP
Substanzen Caffeine, ethosuximide, primidone, carbamazepine, phenytoin, 2-ethyl-2-phenylmalonamide monohydrate
Schlüsselwörter (U)HPLC, RP, AZURA, P 8.1L, anti-epileptic drugs, high throughput, analysis time, band broadening, extra column volume, symmetry, van Deemter, system volumes
CAS Nummer 80866-90-6, 58-08-2, 77-67-8, 125-33-7, 298-46-4, 57-41-0
Version version 1 06/2023

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