This new automated lipid nanoparticle (LNP) formulation system, the IJM NanoScaler Pro, addresses the long-standing challenges in the field of mRNA and LNP formulation. It eliminates the need for lab-intensive and time-consuming experiments. The IJM NanoScaler Pro significantly reduces the time and material costs associated with screening for the optimal LNP formulation.
With our Impingement Jets Mixing (IJM) technology for LNP production and automated lipid and API sampling, the IJM NanoScaler Pro allows researchers to fine-tune encapsulation conditions for their API-based therapy. In addition, integrated UV monitoring facilitates the controlled collection of your formulation sample and minimizes sample loss.
In addition to accelerating research, the IJM NanoScaler Pro offers scalability by utilizing the same IJM technology as KNAUER’s GMP production systems. This seamless transition from small-scale experimentation to large-scale production reduces costs while accelerating discoveries in the field of LNP-based therapeutics and personalized medicine. It is an invaluable asset to the scientific and medical communities seeking to advance the formulation of lipid nanoparticles.
You can upgrade your NanoScaler to the Pro version with the NanoScaler Pro Upgrade Kit (A71105), consisting of devices, software upgrade and capillaries.
IJM NanoScaler Pro
Flow scheme of the IJM NanoScaler Pro
Highly reproducible results
Flexible and modular
Customized solutions
Certified quality management
Made in Germany
| Fields of applications | LNP Research and Development (R&D) |
|---|---|
| Number of impingement jets mixers | 5 |
| Number of pumps | 3 |
| Number of valves | 2 |
| Process connection inlet | 1/8“ OD, 2.1 mm, ID FEP tubing (UNF 1/4-28 thread, flat bottom) |
| Process connection outlet | 1/16“ OD, 0.5 mm, ID PEEK tubing (UNF 10-32, thread coned) |
| Volumetric flow rate (L/min) | up to 0.05 liter/min |
| Volumetric flow rate (L/hour) | 3 |
| Maximum operation pressure | 140 bar (2030 psi) |
| Liquid temperature range | 4−60 °C (39.2−140 °F) |
| Wetted materials | Titanium, stainless steel, PEEK, GFP (graphite fiber reinforced PTFE), FFKM, PTFE, FEP, UHMW PE, ruby, aluminum oxide (Al2O3), sapphire, Zirconium oxide, POM, Tefzel® (ETFC) |
| Software | CDS, 21 CFR part 11 compliant |
| Ambient conditions | Temperature range: 4–40 °C; 39.2–104 °F; humidity: below 90 % (non condensing) |
Expand the IJM NanoScaler with an additional injection valve - minimise the consumption of encapsulation material for the production of nanoparticles in small quantities
Article No.: A71103
Show product
Expand the IJM NanoScaler with three additional flow meters - monitor the flow rate of all pumps for product and process control
Article No.: A71114
Show product
KNAUER is known for the quality of its products and has been certified several times. We produce high-tech laboratory instruments for research, routine analysis and production.
See all Quality certificates
In addition, we have extended documentation about all our products, including CE Declarations of Conformity.
See all CE Declarations of conformity
Innovation and quality - since 1962. Made in Germany.
We are happy to help you
Mo – Fr
07:00 – 17:00 CE(S)T
24 / 7
Technical data or prices are subject to change without notice. Prices may vary by country and do not include taxes, customs duties or delivery. All trademarks are the property of their respective owners.Our general terms and conditions apply: www.knauer.net/terms
